Proxy Mobile IPv6 (PMIPv6) is a network-based mobility management protocol for localized domains, which has been actively standardized by the IETF NETLMM Working Group. PMIPv6 is starting to attract much attention among telecommunication and internet communities due to its salient features and it is expected to expedite the real deployment of IP-based mobility management. However, an experimental evaluation of PMIPv6 which analyzes the impact of its practical constrains is still missing. From their analysis it is possible to highlight the requirements for PMIPv6's real implementation and to accelerate the practical deployment of IP-based network mobility management. In this paper, we present an experimental evaluation of PMIPv6 under different implementation configurations and we evaluate their impact on the performance of PMIPv6 in a real test-bed.